SIMULATION OF MOLECULAR DOCKING FATTY ACID CONSTITUENTS OF SNAKEHEAD FISH (Channa striata) ON FFAR4/GPR120

Authors

  • Mega Kartikasari Program Studi Farmasi Fakultas Kesehatan Universitas Harapan Bangsa, Jalan Raden Patah No. 100, Ledug, Purwokerto, Kabupaten Banyumas, Jawa Tengah 53182, Indonesia
  • Syaiful Prayogi Progam Studi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban, Jalan Raya Pagojengan Km 3 Paguyangan Brebes, Jawa Tengah 52276, Indonesia
  • Lukman Hakim Program Studi Farmasi Fakultas Kesehatan Universitas Harapan Bangsa, Jalan Raden Patah No. 100, Ledug, Purwokerto, Kabupaten Banyumas, Jawa Tengah 53182, Indonesia
  • Feri Kanti Rahayu Program Studi Farmasi Program Sarjana (S-1), Universitas Bhakti Mandala Husada Slawi, Indonesia

Abstract

In diabetes (Type 2 DM) the production of pro-inflammatory cytokines is high. FFAR4/GPR120 is a free fatty acid receptor that plays a role in reducing pro-inflammatory cytokines. This study was conducted with the aim of estimating the interaction of fatty acid constituents in snakehead fish with FFAR4. The crystal structure of FFAR4 protein was made using homology modeling, the test compounds were used using Marvin Sketch, BDS and MVD were used for docking simulation and visualization. Melatonin receptor type 1B with a Seq Identity value of 26.69% was chosen as a template in homology modeling to produce the FFAR4 model (Ramachandran Favored (91.67%)). Research shows DHA with a rerank score of -78.843 has the best binding between the other 2 fatty acids.

Keywords:    Channa striata, DHA, free fatty acid, hyperglycemia

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Published

2023-02-06

How to Cite

Kartikasari, M., Prayogi, S., Hakim, L. ., & Rahayu, F. K. (2023). SIMULATION OF MOLECULAR DOCKING FATTY ACID CONSTITUENTS OF SNAKEHEAD FISH (Channa striata) ON FFAR4/GPR120. Pharmacy Peradaban Journal, 3(1). Retrieved from https://journal.peradaban.ac.id/index.php/ppj/article/view/1338

Issue

Vol. 3 No. 1 (2023): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban

Section

Vol 2 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Univer