Interaksi Senyawa dari Mutingia calabura terhadap DPP4: In Silico

Abstract

Diabetes Mellitus (DM) is a degenerative disease that is a big problem in the world of health.  Treatment of DM, especially type 2 DM, usually uses synthetic drugs which have side effects.  Dipeptidyl Peptidase 4 (DPP4) enzyme inhibitor drugs have not been widely studied and have potential for hypoglycemia. This research aims to examine compound isolates from the cherry plant (Mutingia calabura) in inhibiting the DPP4 enzyme in silico.  Molecular docking is carried out through several stages including modeling and optimization of compound structures, preparation of target proteins and ligands, validation of docking, docking processes, and visualization of interactions. Nine test compounds (active compounds from Mutingia calabura) can bind to the DPP4 enzyme. All compounds have lower binding energies compared to the reference vidagliptin