STUDY OF MOLECULAR DOCKING LIGANS IN Glucagon Like-Peptide-1 Receptor (GLP-1R)

Authors

  • Lukman Hakim Program Studi Farmasi Fakultas Kesehatan Universitas Harapan Bangsa, Jalan Raden Patah No. 100, Ledug, Purwokerto, Kabupaten Banyumas, Jawa Tengah 53182, Indonesia
  • Syaiful Prayogi Progam Studi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban, Jalan Raya Pagojengan Km 3 Paguyangan Brebes, Jawa Tengah 52276, Indonesia
  • Mega Kartikasari Program Studi Farmasi Fakultas Kesehatan Universitas Harapan Bangsa, Jalan Raden Patah No. 100, Ledug, Purwokerto, Kabupaten Banyumas, Jawa Tengah 53182, Indonesia
  • Feri Kanti Rahayu Program Studi Farmasi Program Sarjana (S-1), Universitas Bhakti Mandala Husada Slawi, Indonesia

Abstract

Hyperglycemia is associated with relatively specific long-term microvascular complications and an increased risk of cardiovascular disease. The effectiveness of reducing A1C GLP-1 allows Glucagon Like-Peptide-1 Receptor (GLP-1R) to be an attractive option as a target for diabetes drugs. This study was conducted with the aim of estimating the interaction of several ligands with GLP-1R. Test ligands were used using Marvin Sketch, BDS and MVD were used for docking simulation and visualization. The study showed that the 4 constituent compounds in snakehead fish had potential binding among other test compounds.

Keywords: Channa striata, free fatty acids, hyperglycemia

Downloads

Published

2023-02-06

How to Cite

Hakim, L. ., Prayogi, S., Kartikasari, M., & Rahayu, F. K. (2023). STUDY OF MOLECULAR DOCKING LIGANS IN Glucagon Like-Peptide-1 Receptor (GLP-1R). Pharmacy Peradaban Journal, 3(1). Retrieved from https://journal.peradaban.ac.id/index.php/ppj/article/view/1337

Issue

Vol. 3 No. 1 (2023): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban

Section

Artikel