STUDY OF MOLECULAR DOCKING LIGANS IN Glucagon Like-Peptide-1 Receptor (GLP-1R)
Hyperglycemia is associated with relatively specific long-term microvascular complications and an increased risk of cardiovascular disease. The effectiveness of reducing A1C GLP-1 allows Glucagon Like-Peptide-1 Receptor (GLP-1R) to be an attractive option as a target for diabetes drugs. This study was conducted with the aim of estimating the interaction of several ligands with GLP-1R. Test ligands were used using Marvin Sketch, BDS and MVD were used for docking simulation and visualization. The study showed that the 4 constituent compounds in snakehead fish had potential binding among other test compounds.
Keywords: Channa striata, free fatty acids, hyperglycemia